Bladder tissue regeneration

S.C. Baker and J. Southgate,     The University of York, UK


organ donor shortages have driven the search for tissue engineering and regenerative solutions in many tissue pathologies, but disorders of the urinary bladder have no allograft solution. Currently, end-stage bladder disease is addressed by reconstructing the bladder with vascularised segments of bowel, but serious long-term side-effects correspond to a clinical need to develop new approaches. the application of electrospun biomaterials, in combination with in vitro tissue engineering or in vivo regenerative engineering strategies, holds elusive promise for routine bladder augmentation or substitution. The major challenges include identification ...

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