Cell culture systems for kidney research
L.A. Bosworth and S. Schüler
R. Lennon, The University of Manchester, UK
the kidney glomerulus is a highly sophisticated size selective filter, where in glomerular disease, filtration is impaired. This results in protein and even cells leaking across the glomerular barrier from the blood into the urine. Persistent protein leak leads to kidney failure, which has significant associated morbidity and cost. New therapies are needed to restore or preserve the glomerular barrier function. However, to design new therapies we need to build up an understanding of basic disease mechanisms. within the glomerulus, specialised epithelial cells called podocytes are a vital component of the barrier. ...