March 2018
Intermediate to advanced
904 pages
29h 36m
English
book
Emerging Areas in Bioengineering
by Ho Nam Chang, Sang Yup Lee, Jens Nielsen, Gregory Stephanopoulos
Content preview from Emerging Areas in Bioengineering
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Chapter 6Design of Artificial Supramolecular Protein Assemblies by Enzymatic Bioconjugation for Biocatalytic Reactions
Geisa A.L.G. Budinova, Yutaro Mori and Noriho Kamiya
Concise Definition of Subject
Self-assembly processes in biological systems generate well-organized, higher-order protein structures with unique functions. Protein cross-linking can occur by covalent or non-covalent linkage of proteins that have natural affinity in vivo, generating intrinsic architectures, such as viral particles, cell-surface pilus nanoarchitectures, and biomass degrading nanomachines (e.g., cellulosome). To mimic this singular natural biomolecular assembly system, the design of artificial conjugates is becoming very attractive. Several strategies have ...