Chapter 29Advanced Short Tandem Repeat Genotyping for Forensic Human Identification
Yong T. Kim, Hyun Y. Heo and Tae S. Seo
The human genome project reveals that eukaryotic genomes are rich with repeated DNA sequences typically in the noncoding intron region. In particular, the DNA regions with repeat units of 2–7 bp in length, called microsatellites or short tandem repeats (STRs), are highly polymorphic among individuals [1, 2]. Facile coamplification of STR markers and the high discrimination of STR patterns endow STR genotyping with a gold standard method in modern forensic societies to be applied for human identification.
The general STR typing procedure performed in the forensic laboratory consists of the DNA extraction from the biological ...
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