Chapter 39Mass Production of Full-Length IgG Monoclonal Antibodies from Mammalian, Yeast, and Bacterial Hosts

Sang T. Jung and Dong-Il Kim

IgG antibodies are tetramers formed by the assembly of two identical heavy chains and two light chains and are critical modulators of various immune responses (Figure 39.1). Since 1975 when Georges Köhler and Cesar Milstein developed hybridoma technology, mAbs have been utilized extensively for therapeutic and diagnostic applications. Due to many advantages over conventional chemically synthesized drugs, in particular, in terms of target specificity and serum half-lives, mAbs have been considered one of the most potent and effective biopharmaceutics used to treat cancer, infectious diseases, inflammation, ...

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