Chapter 44Software Applications for Phenotype Analysis and Strain Design of Cellular Systems
Meiyappan Lakshmanan, Lokanand Koduru and Dong-Yup Lee
44.1 Introduction
Systems biology is an interdisciplinary field that aims at generating highly accurate in silico models with the available affluent omics data generated by high-throughput technologies [1]. These models promise to suggest experimentally testable hypotheses on underlying mechanisms as well as quantitatively predict the physiological behavior of complex biological systems. Several approaches for modeling cellular systems include kinetic modeling, Bayesian methods, constraint-based flux modeling, and Boolean approaches. Among them, the constraint-based reconstruction and analysis ...
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