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Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices

Book Description

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices covers the modern micro and nanotechnologies used for diagnosis, drug delivery, and theranostics using micro, nano, and implantable systems. In-depth coverage of all aspects of disease treatment is included.

In addition, the book covers cutting-edge research and technology that will help readers gain knowledge of novel approaches and their applications to improve drug/agent specificity for diagnosis and efficient disease treatment. It is a comprehensive guide for medical specialists, the pharmaceutical-industry, and academic researchers discussing the impact of nanotechnology on diagnosis, drug delivery, and theranostics.

  • Gives readers working in immunology, drug delivery, and medicine a greater awareness on how novel nanotechnology orientated methods can help improve treatment
  • Provides readers with backgrounds in nanotechnology, chemistry, and materials science an understanding on how nanotechnology is used in immunology and drug delivery
  • Includes focused coverage of the use of nanodevices in diagnostics, therapeutics, and theranostics not offered by other books

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. List of Contributors
  6. Editor Biographies
  7. Chapter 1. Therapeutic Applications of Polymeric Materials
    1. 1. Introduction
    2. 2. Polymers as Drug Delivery Systems
    3. 3. Polymers in Imaging and Diagnosis
    4. 4. Conclusion
  8. Chapter 2. Multifunctional Micro- and Nanoparticles
    1. 1. Introduction
    2. 2. Micro- and Nanomaterials in the Synthesis of Multifunctional Carriers
    3. 3. Types of Functional Moieties
    4. 4. Functionalization of Micro- and Nanoparticles
  9. Chapter 3. Nanomicelles in Diagnosis and Drug Delivery
    1. 1. Introduction
    2. 2. Nanomicelle Preparation
    3. 3. Application of Nanomicelle in Diagnostics and Imaging
    4. 4. Application of Nanomicelles in Drug Delivery
    5. 5. Conclusion
  10. Chapter 4. Diagnosis and Drug Delivery to the Brain: Novel Strategies
    1. 1. Introduction
    2. 2. Barriers for Brain Drug Delivery
    3. 3. Physiology of the Blood–Brain Barrier
    4. 4. Invasive Drug Delivery Approaches
    5. 5. Noninvasive Drug Delivery Approaches
    6. 6. Nanotechnology Approaches
    7. 7. Active Blood–Brain Barrier Targeting Strategies
    8. 8. Novel Nanoplatforms and Delivery Vehicles for BBB Targeting
    9. 9. Development of Neurodiagnostic Nanoimaging Platforms
    10. 10. Conclusion
  11. Chapter 5. Emerging Nanotechnology for Stem Cell Therapy
    1. 1. Introduction
    2. 2. Application of Nanoparticles in Isolation of Stem Cells
    3. 3. Application of Nanoparticles in Stem Cell Tracking
    4. 4. Role of Nanotechnology in Regulating Microenvironment of Stem Cells: Potential Roles in Tissue Engineering
    5. 5. Nanoparticles as Macromolecular Delivery Systems for Stem Cells
    6. 6. Future Prospects and Challenges Facing the Field
  12. Chapter 6. Nanoparticulate Systems for Therapeutic and Diagnostic Applications
    1. 1. Introduction
    2. 2. Why Nanotechnology and Nanomedicine?
    3. 3. Types of Nanoparticles in Drug Delivery
    4. 4. Conclusion
  13. Chapter 7. Peptide and Protein-Based Therapeutic Agents
    1. 1. Introduction
    2. 2. Challenges With Peptide and Protein Therapeutics
    3. 3. Chemical Modifications
    4. 4. Micro- and Nanotechnology for Biologics in Drug Delivery
    5. 5. Protein- and Peptide-Based Therapeutics
    6. 6. Conclusion
  14. Chapter 8. Nanotechnology in Intracellular Trafficking, Imaging, and Delivery of Therapeutic Agents
    1. 1. Introduction
    2. 2. Mechanisms
    3. 3. Macropinocytosis
    4. 4. Conclusion
  15. Chapter 9. Electrospun Nanofibers in Drug Delivery: Fabrication, Advances, and Biomedical Applications
    1. 1. Introduction
    2. 2. Stimuli-Responsive Nanofibers in Drug Delivery Applications
    3. 3. Applications of Electrospun Nanofibers
    4. 4. Conclusion
  16. Chapter 10. Nanosystems for Diagnostic Imaging, Biodetectors, and Biosensors
    1. 1. Introduction
    2. 2. Nanosystems as Platforms for Advanced Diagnostic Imaging
    3. 3. Diagnostic Imaging With Nanosystems
    4. 4. Biological Sensors
    5. 5. Conclusions
  17. Chapter 11. Micro- and Nanotechnology-Based Implantable Devices and Bionics
    1. 1. Introduction
    2. 2. Biocompatibility Issues of Implants
    3. 3. Microtechnology-Based Implantable Devices and Bionics
    4. 4. Nanotechnology-Based Implantable Devices and Bionics
    5. 5. Conclusions and Future Perspectives
  18. Chapter 12. Solid Lipid Nanoparticles in Drug Delivery: Opportunities and Challenges
    1. 1. Introduction
    2. 2. Components of Solid Lipid Nanoparticles
    3. 3. Solid Lipid Nanoparticle Production Techniques
    4. 4. Drug-Loading Capacity of Solid Lipid Nanoparticles
    5. 5. Drug Incorporation Models of Solid Lipid Nanoparticles
    6. 6. Drug Release From Solid Lipid Nanoparticles
    7. 7. Applications of Solid Lipid Nanoparticles for Drug Delivery
    8. 8. Stability Concerns of Solid Lipid Nanoparticles
    9. 9. Toxicity Aspects of Solid Lipid Nanoparticles
    10. 10. Diagnostic Applications of Solid Lipid Nanoparticles
    11. 11. In Vivo Fate of Solid Lipid Nanoparticles
    12. 12. Conclusions
  19. Chapter 13. Microneedles in Drug Delivery
    1. 1. Introduction
    2. 2. Skin Structure and Barrier to Transdermal Delivery
    3. 3. Microneedles
    4. 4. Selection of Microneedle Designs for Applications
    5. 5. Commercial Microneedle Devices
  20. Chapter 14. Nanotechnology-Based Medical and Biomedical Imaging for Diagnostics
    1. 1. Introduction
    2. 2. Fluorescence-Based Imaging and Diagnostics
    3. 3. Nanocarriers in Biological Imaging
    4. 4. Photoacoustic and Ultrasound Imaging
    5. 5. Conclusions
  21. Chapter 15. Drug and Gene Delivery Materials and Devices
    1. 1. Introduction
    2. 2. Advances in Delivery Systems
    3. 3. Gene Delivery
    4. 4. Gene Therapy Products
    5. 5. Conclusion and Future Direction
  22. Index