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Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices by Abhirup Mandal, Kishore Cholkar, Ashim K Mitra

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Chapter 3

Nanomicelles in Diagnosis and Drug Delivery

Hoang M. Trinh1, Mary Joseph1, Kishore Cholkar2, Ranjana Mitra1, and Ashim K. Mitra1     1University of Missouri–Kansas City, Kansas City, MO, United States     2Ingenus Pharmaceuticals/RiconPharma LLC, Denville, NJ, United States

Abstract

Nanomicelles are colloidal constructs composed of amphiphilic monomers and have two parts, a small hydrophobic head and a long hydrophilic tail. The hydrophobic core interacts with hydrophobic drugs/agents, whereas the hydrophilic tail helps surrounding with water and enhances solubility. Therefore nanomicelles can encapsulate hydrophobic drugs as well as imaging agents to improve the sensitivity of imaging and diagnosis. Nanomicelles offer many advantages, ...

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