February 2017
Intermediate to advanced
416 pages
14h 52m
English
book
Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices
by Ashim K Mitra, Kishore Cholkar, Abhirup Mandal
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Chapter 4
Diagnosis and Drug Delivery to the Brain
Novel Strategies
Abstract
For decades, tremendous efforts have been made by biomedical and pharmaceutical researchers to treat diseases affecting the central nervous system (CNS). The blood–brain barrier effectively protects the brain, but poses a formidable challenge to drug delivery. Many conventional drugs cannot cross the BBB in therapeutic concentrations (less than 1%). As a result proper treatments of various CNS diseases such as Alzheimer, brain tumors, and human immunodeficiency virus infection are compromised. ...
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