Chapter 4

Diagnosis and Drug Delivery to the Brain

Novel Strategies

Abhirup Mandal1, Rohit Bisht2, Dhananjay Pal1, and Ashim K. Mitra1     1University of Missouri–Kansas City, Kansas City, MO, United States     2University of Auckland, Auckland, New Zealand

Abstract

For decades, tremendous efforts have been made by biomedical and pharmaceutical researchers to treat diseases affecting the central nervous system (CNS). The blood–brain barrier effectively protects the brain, but poses a formidable challenge to drug delivery. Many conventional drugs cannot cross the BBB in therapeutic concentrations (less than 1%). As a result proper treatments of various CNS diseases such as Alzheimer, brain tumors, and human immunodeficiency virus infection are compromised. ...

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