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Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology by Quoc Nam Tran, Hamid R Arabnia

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Chapter 22

DNA Double-Strand Break–Based Nonmonotonic Logic

Andrei Doncescu1; Pierre Siegel2    1 University Paul Sabatier – INSERM – CNRS, CRCT, France2 Aix Marseille University, CNRS, LIF, Marseille, France

Abstract

Biological systems are complex systems with a dynamic evolution in terms of structure and biological causality. In order to model and control these systems, we must observe and simulate their behavior using relevant models. This chapter introduces a logical model based on default logic for DNA double-strand break (DSB) modeling. This new approach handles the uncertainties of knowledge and missing information concerning the conditions of activation/inhibition of some proteins. This model can be applied to any signaling pathway, ...

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