Using Methylation Patterns for Reconstructing Cell Division Dynamics
Assessing Validation Experiments
D.J. Andrews; A.G. Lynch; S. Tavaré Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
Abstract
Methylation patterns present in a cell population can inform us about the way the cells are organized and how the population is sustained. Methylation is inheritable through cell divisions but changes can occur as a result of methylation replication errors. Hence, variation in methylation patterns in a cell population at a given time captures information about the history of the cell population. It is important that the observed methylation patterns are representative of those in the cell population. ...
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