Architectural Topography of the α-Subunit Cytoplasmic Loop in the GABAA Receptor
J.L. Mustard; J.B. Worley; N.W. Seidler Division of Basic Sciences, Laboratory of Bioinformatics and Computational Biology, Kansas City University of Medicine and Biosciences, Kansas City, MO, United States
Abstract
γ-Aminobutyric acid type A receptor, is a neurotransmitter-gated chloride channel that controls neuronal inhibition and is a crucial target for pharmacological intervention. The ligand-binding and transmembrane domains are highly conserved, well-characterized, and comprehensively studied. However, the intracellular loop domain (ILD) is strikingly variable among the subunit subtypes, and its structure is still a mystery. Using computational ...
Get Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology now with the O’Reilly learning platform.
O’Reilly members experience books, live events, courses curated by job role, and more from O’Reilly and nearly 200 top publishers.
