Finding Long-Term Influence and Sensitivity of Genes Using Probabilistic Genetic Regulatory Networksa
Q.N. Tran The University of South Dakota, Vermillion, SD, United States
Abstract
Investigation of the gene’s long-term behavior becomes more important in understanding the interactions between different genes and how the genes collectively behave. It has been known for a long time by biologists that some genes may have more impact than others in determining the value of a target gene. Probabilistic Boolean genetic regulatory networks (PBNs), the stochastic generalizations of Boolean networks, have been used in system biology to study biological systems from a holistic perspective in providing a comprehensive, system-level understanding ...
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