Book description
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.
Table of contents
- Title Page
- Copyright Page
- Dedication Page
- Contents
- Acknowledgments
- About the Authors
- 1. Historical perspective
- 2. Chromatin dynamics and chromatin remodeling in animals
- 3. Chromatin dynamics and chromatin remodeling in plants
- 4. DNA methylation as epigenetic mechanism
- 5. Histone modifications and their role in epigenetic regulation
- 6. Realm of non-coding RNAs: From bacteria to human
- 7. Non-coding RNAs involved in epigenetic processes: A general overview
- 8. Non-coding RNAs across the kingdoms—bacteria and Archaea
- 9. Non-coding RNAs across the kingdoms—protista and fungi
- 10. Non-coding RNAs across the kingdoms—animals
- 11. Non-coding RNAs across the kingdoms—plants
- 12. Non-coding RNAs—comparison of biogenesis in plants and animals
- 13. Paramutation, transactivation, transvection, and cosuppression—silencing of homologous sequences
- 14. Bacterial adaptive immunity—Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
- 15. Gene silencing—ancient immune response and a versatile mechanism of control over the fate of foreign nucleic acids
- 16. Epigenetics of germline and epigenetic memory
- 17. Epigenetics of health and disease—cancer
- 18. Epigenetics of health and disease—behavioral neuroscience
- 19. Epigenetics of health and disease—diet and toxicology, environmental exposures
- 20. Epigenetics and technology—hairpin-based antisensing
- Index
Product information
- Title: Epigenetics in Health and Disease
- Author(s):
- Release date: May 2012
- Publisher(s): Pearson
- ISBN: 9780132599283
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