3

DNA Replication

CONCEPT OUTLINE
  • Introduction
  • Chemistry of DNA Synthesis
  • Modes of DNA Replication
  • Semi-conservative Mode of Replication/Meselson and Stahl Experiment
  • Enzymes of Replication
    • Prokaryotic DNA polymerases
    • Helicases
    • Primases
    • Single-strand binding proteins
    • Ligases
    • Topoisomerases
  • Models of Replication
    • θReplication
    • Rolling circle replication
    • Bacteriophage ϕ ×174 replicates by rolling circle replication
    • D-loop replication
  • Prokaryotic Replication
    • Origin of replication
    • Initiation of DNA replication
    • Fidelity of DNA replication
  • Eukaryotic Replication
    • Cell cycle
    • Cell cycle control of DNA replication
    • Eukaryotic replication origins
    • Initiation of DNA replication
    • Elongation
    • Licensing of DNA replication
    • Termination of replication
    • Telomeres ...

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