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Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
Basic exposure and exposure–response models 27
1E
max
/(1+EC
50
/c
i
) is too clo se to zero. Often a very small positive number
can be added or E
max
is bounded lower than 1 to avoid this problem. E
max
can be negative if the e xposure effect is to increase y
i
from y
i0
.
Finally, it is important to note that dealing with zero exposur es (e.g.,
exposure of the control group) is difficult for log-transformation, e.g., log(y
i
) =
β log(c
i
) + ε
i
. T he ad hoc approach of replacing the zero value with a small
value may work fine. But sensitivity of the model fitting to the imputed value
should be examined. If the purpose is to extrapolate the exposure–response
relationship ...
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Publisher Resources

ISBN: 9781466573215