Chapter 10Integrated Models
Learning Objectives
- Implement dynamic time-course simulations using FBA
- Integrate transcriptional regulation with metabolic network modeling
- Understand how integrating heterogeneous modeling approaches enables whole-cell models
This book ends with a topic that I’ve been obsessed with for almost 15 years: the quest to build “whole-cell” models that consider every known gene and molecule. This obsession began just as I started graduate school, when I read an article in The New York Times (Wade, 1999) that quoted Clyde Hutchison, who studies Mycoplasma, as saying:
The ultimate test of understanding a simple cell, more than being able to build one, would be to build a computer model of the cell, because that really ...
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