Fundamentals of Systems Biology

Chapter 7Transcriptional Regulation

Learning Objectives

• Identify the major motifs in gene transcriptional regulatory networks
• Calculate the dynamic properties associated with these motifs using multiple methods
• Compare model outputs with corresponding experimental data
• Understand how simpler motifs combine to form larger, more complex motifs

You’ve seen most of the commonly used approaches to modeling biological networks, and you’ve applied these approaches to some relatively simple circuits. Now it’s time to extend these techniques to larger, more complicated biological systems! Section II will lead you through the strategies that researchers have used to tackle three kinds of biological networks at a larger scale: transcriptional regulation, ...