8. Genes and genomes in cancer: targeted therapies
The goal of this chapter is to consider advances in the understanding of the biology of tumors through genomic and genetic studies. These studies have increasingly led to delineation of specific signaling pathways that are impacted in tumors. Insights into these pathways have led to advances in cancer therapy. However, technologies that enable in-depth analysis of the clones within tumors reveal the extent of genomic changes that occur in tumors and the difficulty in distinguishing driver mutations that are key in tumor progression from passenger mutations that may play secondary roles in progression.
Molecular studies in tumors and therapeutic developments
In a review of the history of cancer ...