Genetics and Genomics

HIV attachment to target T cell. Some of the mutant with ∆32/∆32 genotype in the population render with no ccr5 receptors on the surface of T cell making resistant to HIV strain.

(SOURCE: SHUTTERSTOCK).

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POPULATION GENETICS

CONCEPT OUTLINE

Population, Gene frequencies and Gene pool

Hardy–Weinberg Law

■ Predicting equilibrium

■ Generalized equation

■ Testing of equilibrium

■ Taster – nontaster trait

■ M–N allele frequency

■ HIV-1 susceptibility and CCR5-Δ32 allele frequency

Application of Hardy–Weinberg law

■ Frequencies in Two alleles system

■ Frequencies in Multiple alleles system

■ Frequencies in Sex-linked genes

Extension of Hardy–Weinberg ...