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Advanced Maternal Age

CHAPTER OBJECTIVES
  • Aneuploidies and Advanced Maternal Age
  • Autosomal Aneuploidies
ANEUPLOIDIES AND ADVANCED MATERNAL AGE

Aneuploidy is a numerical chromosomal abnormality that occurs as a consequence of non-disjunction. Non-disjunction is the failure of chromosome pairs to segregate properly during meiosis. Non-disjunction can occur during meiosis I or meiosis II or mitosis, and this results in imbalance in the diploid state of the cell. Such a cell is called an aneuploid cell.

Loss of a single chromosome (2n−1), in which the daughter cell(s) will have one chromosome missing from one of its pairs, is referred to as monosomy. Gaining a single chromosome, in which the daughter cell(s) will have one chromosome in ...

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