Advanced Maternal Age
- Aneuploidies and Advanced Maternal Age
- Autosomal Aneuploidies
Aneuploidy is a numerical chromosomal abnormality that occurs as a consequence of non-disjunction. Non-disjunction is the failure of chromosome pairs to segregate properly during meiosis. Non-disjunction can occur during meiosis I or meiosis II or mitosis, and this results in imbalance in the diploid state of the cell. Such a cell is called an aneuploid cell.
Loss of a single chromosome (2n−1), in which the daughter cell(s) will have one chromosome missing from one of its pairs, is referred to as monosomy. Gaining a single chromosome, in which the daughter cell(s) will have one chromosome in ...