Biocompatibility of implantable systems

J.J. Ramsden,     Collegium Basilea (Institute of Advanced Study) Switzerland


The essence of biocompatibility is the ability to interact with proteins without denaturing them. The issue is, therefore, a question of interfacial interactions. In some cases, a simple mean-field approach based on mesoscale surface tension determinations can be a guide. However, the recently gained understanding that the stability of the majority of known proteins is ruled by the degree of desolvation of structure-determining backbone hydrogen bonds, implies that microscopic considerations of local interfacial interactions are required to predict the behaviour of proteins brought into contact with an artificial ...

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