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Biocompatibility of implantable systems

J.J. Ramsden,     Collegium Basilea (Institute of Advanced Study) Switzerland

Abstract:

The essence of biocompatibility is the ability to interact with proteins without denaturing them. The issue is, therefore, a question of interfacial interactions. In some cases, a simple mean-field approach based on mesoscale surface tension determinations can be a guide. However, the recently gained understanding that the stability of the majority of known proteins is ruled by the degree of desolvation of structure-determining backbone hydrogen bonds, implies that microscopic considerations of local interfacial interactions are required to predict the behaviour of proteins brought into contact with an artificial ...

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