12 Pharmaceutical Industry Challenges and Opportunities for Establishing Pharma 4.0

Wenqian Chena,*, Sung Joon Parkb, Thomas Nok Hin Chenga, Nicholas Wai Hoi Laua, Liang Fa Khawc, Dan Lee-Laned, Xizhong Chene, and Muhsincan Sesenf

a Department of Chemical Engineering, Imperial College London, London, UKb Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, Australiac Department of Chemical & Petroleum Engineering, UCSI University, Cheras, Kuala Lumpur, Malaysiad ABB Ltd, Oldends Lane, Stonehouse, UKe Process and Chemical Engineering, School of Engineering and Architecture, University College Cork, Cork, Irelandf Department of Bioengineering, Imperial College London, London, UK* Corresponding author. Department of Chemical Engineering, Imperial College London, London, UK

12.1 Pharma 4.0: Smart Manufacturing for the Pharmaceutical Industry

The progress of human civilization has been powered by the advancements in the mode of manufacturing. Industry 1.0 refers to the use of water- and steam-powered mechanical facilities for manufacturing in the 19th century. In contrast, Industry 2.0 refers to the mass production enabled by electrically powered facilities and labor division in the first half of 20th century [1]. Since the mid to late 20th century, we have been benefiting from Industry 3.0, in which manufacturing is highly automated through the use of electronics and information technology.

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