June 2011
Intermediate to advanced
224 pages
5h 1m
English
book
Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility
by Moyra Smith
Content preview from Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility
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6. Dynamic function, synaptic activity, and plasticity
The goal of this chapter is to present a few examples of insights gained into neuronal and brain functions through molecular genetic studies, facilitated by the availability of data on gene sequence. Through functional genomic studies on synapses, we have gained insight into processes that, when disrupted, lead to cognitive impairment and behavioral abnormalities.
Synapses, dendrites, and cognitive impairment
Histological studies on the brain have revealed that abnormal dendritic spine number and morphology are among the most consistent findings associated with cognitive impairment. A growing body of evidence indicates synaptic plasticity and changes in signal strength following activity, ...
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I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.