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Ion Beam Treatment of Polymers, 2nd Edition by Marcela Bilek, Alexey Kondyurin

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Biological and medical applications

Modern polymers have wide ranging applications in biology and medicine. A key determinant of biocompatibility for implantable biomedical devices is the interaction of its surfaces with proteins in the organism. The ion implanted polymer surface forms strong covalent bonds with proteins, resulting in total coverage of the surface, whilst preserving the biological properties (conformation and activity) of the proteins. The ion implantation of polymer surfaces opens up the possibility of functionalizing the surface for cell attachment with a coating of extracellular matrix or adhesion proteins. The modified polymer surface then becomes completely covered with living cells. In the case of the ion-modified polymer, ...

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