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It Takes a Genome: How a Clash Between Our Genes and Modern Life Is Making Us Sick by Greg Gibson

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Genomewide Association

Until the middle of 2006, the search for new genes that influence disease was pretty much restricted to studies of extended families. Typically, geneticists would identify pedigrees in which a particular type of cancer or heart disease was unusually common and look for parts of the genome that affected individuals have in common. This approach, called linkage mapping, has been the main method for finding single gene disorders, but has had limited success for more complex diseases.

Your parents have between them four copies of every gene. You have two of these, and your children each have a 50-50 chance of receiving each one. Suppose now that you, your father, and two of your three kids have a heart murmur, and both of ...

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