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It Takes a Genome: How a Clash Between Our Genes and Modern Life Is Making Us Sick by Greg Gibson

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6. Generating depression

creative depression It is amazing how many world leaders and entertainers have suffered from the disease.

an epidemic of mood swings Depression is on the rise, afflicting well more than 1 in 10 people at some point in their life.

bipolar and monopolar disorders Each, with differing degrees of severity, are much more than prolonged sadness.

the pharmacology of despair Serotonin and cortisol are a neurotransmitter and a hormone that jointly regulate mood.

misbehaving serotonin Genetic variation in the serotonin transporter is associated with some measures of depression and suicide, particularly if life is stressful.

faint genetic signals It seems likely that hundreds if not thousands of genetic variants contribute to mood ...

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