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JMP 11 Design of Experiments Guide by SAS Institute

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Introduction to Space-Filling Designs
Space-filling designs are useful for modeling systems that are deterministic or near-deterministic. One example of a deterministic system is a computer simulation. Such simulations can be very complex involving many variables with complicated interrelationships. A goal of designed experiments on these systems is to find a simpler empirical model that adequately predicts the behavior of the system over limited ranges of the factors.
In experiments on systems where there is substantial random noise, the goal is to minimize the variance of prediction. In experiments on deterministic systems, there is no variance but there is bias. Bias is the difference between the approximation model and the true mathematical ...

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