Machine Learning for Protein Subcellular Localization Prediction

2 Overview of subcellular localization prediction

Protein subcellular localization prediction is to determine the cellular compartment(s) that a protein will be transported to. Traditionally, this problem is solved by purely experimental means through time-consuming and laborious laboratory tests [109]. However, the number of newly found protein sequences has been growing rapidly in the postgenomic era. Therefore, more reliable, efficient, and automatic methods are highly required for the prediction of where a protein resides in a cell. The knowledge thus obtained can help biologists use these newly discovered protein sequences for both basic biological research and drug design [130]. Recent decades have witnessed remarkable progress of in-silico ...