Chapter 17Materials Nanoarchitectonics: Drug Delivery System
Yohei Kotsuchibashi
Shizuoka Institute of Science and Technology, Faculty of Science and Technology, Department of Materials and Life Science, 2200-2 Toyosawa, Fukuroi, Shizuoka, 437-8555, Japan
17.1 Introduction
The origin of the controlled drug delivery system (DDS) using polymeric biomaterials dates back to the 1960s, with materials sizing continuously decreasing from macro (1970s) to micro (1980s), and nano (1990s to present) [1, 2]. Using the Ringsdorf model for polymer drugs [3], various types of nanoparticles were produced in the 2000s. The development of nanoparticles was supported by three key technologies: (i) PEGylation; (ii) passive targeting, that is, solid tumor accumulation ...
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