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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 2

Principles of Drug Action

LEARNING OBJECTIVES
  • Description of the basic chemistry of drugs and their relation to their properties

  • Define the hybridization, isomerism, chirality, stereochemistry, heteroatoms, and aromaticity, and their relation to the physicochemical properties of a drug

  • Define the solubility, protein interaction, and hydrogen bonding related to functional groups present in a drug structure

  • Define acid-base chemistry in relation to drug structure and properties like pKa

  • Define factors important to attain acidity or basicity

  • Importance of heteroatoms in a drug structure, especially nitrogen

  • Explain the drug action and importance of studying physicochemical properties

  • Understand how drug encounters the biological ...

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