Medicinal Chemistry, 2nd Edition

Chapter 2

Principles of Drug Action

LEARNING OBJECTIVES

• Description of the basic chemistry of drugs and their relation to their properties

• Define the hybridization, isomerism, chirality, stereochemistry, heteroatoms, and aromaticity, and their relation to the physicochemical properties of a drug

• Define the solubility, protein interaction, and hydrogen bonding related to functional groups present in a drug structure

• Define acid-base chemistry in relation to drug structure and properties like pK_a

• Define factors important to attain acidity or basicity

• Importance of heteroatoms in a drug structure, especially nitrogen

• Explain the drug action and importance of studying physicochemical properties

• Understand how drug encounters the biological ...