May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 3
Drug Metabolism and Prodrugs
LEARNING OBJECTIVES
Define metabolism
Explain what happens to drug after action
Various reactions that happen in the body
Describe Phase I and Phase II reactions
Define the concept of prodrugs
Explain the need for prodrugs preparation
Define the characteristics of prodrugs
Explain the selective targeting with prodrugs
List the classes of prodrugs
Explain functional group-specific carrier linkages
Describe how poor soluble drugs can be overcome
Describe how bitter drugs can be made edible
Describe how absorption and distribution of drug can be improved
Describe how drugs can be improved upon on stability
Describe how drugs can be made for prolonged release
Describe how toxicity of drugs can be overcome ...
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