Chapter 3

Drug Metabolism and Prodrugs

LEARNING OBJECTIVES
  • Define metabolism

  • Explain what happens to drug after action

  • Various reactions that happen in the body

  • Describe Phase I and Phase II reactions

  • Define the concept of prodrugs

  • Explain the need for prodrugs preparation

  • Define the characteristics of prodrugs

  • Explain the selective targeting with prodrugs

  • List the classes of prodrugs

  • Explain functional group-specific carrier linkages

  • Describe how poor soluble drugs can be overcome

  • Describe how bitter drugs can be made edible

  • Describe how absorption and distribution of drug can be improved

  • Describe how drugs can be improved upon on stability

  • Describe how drugs can be made for prolonged release

  • Describe how toxicity of drugs can be overcome ...

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