Medicinal Chemistry, 2nd Edition

Chapter 3

Drug Metabolism and Prodrugs

LEARNING OBJECTIVES

• Define metabolism

• Explain what happens to drug after action

• Various reactions that happen in the body

• Describe Phase I and Phase II reactions

• Define the concept of prodrugs

• Explain the need for prodrugs preparation

• Define the characteristics of prodrugs

• Explain the selective targeting with prodrugs

• List the classes of prodrugs

• Explain functional group-specific carrier linkages

• Describe how poor soluble drugs can be overcome

• Describe how bitter drugs can be made edible

• Describe how absorption and distribution of drug can be improved

• Describe how drugs can be improved upon on stability

• Describe how drugs can be made for prolonged release

• Describe how toxicity of drugs can be overcome ...