Medicinal Chemistry, 2nd Edition

Chapter 6

Local Anaesthetics

LEARNING OBJECTIVES

• Compare general anaesthetics and local anaesthetics

• List the ideal properties of a local anaesthetics

• Explain the overall mechanisms of action of anaesthetics

• Describe the clinical utility of local anaesthetics

• Categorise the various modes of administration of local anaesthetics

• Learn the discovery pathway of present-day local anaesthetics that originated from natural drug cocaine

• List the various classes of local anaesthetics and their chemical structures

• Describe the synthesis, uses, and doses of benzoic acid class of local anaesthetics

• Describe the mechanism of action of benzocaine and how it is different from other anaesthetics

• Describe the relationship between structure of benzoic acid ...