Medicinal Chemistry, 2nd Edition

Chapter 9

Antipsychotic Agents

LEARNING OBJECTIVES

• Define antipsychotics and their utility in various conditions

• Categorize antipsychotics on the basis of the target at which they act

• Describe the synthetic routes of each antipsychotics

• Define the utility and doses of each antipsychotics

• Describe the mechanism by which antipsychotics act, and their implications

• Define the discovery and functional utility of phenothiazines

• Discuss the structure-activity relationship on phenothiazines

• Describe the neuroleptic SAR of butyrophenone

• Define atypical antipsychotics and the need for design

• Describe some newer drugs for psychosis treatment

9.1 INTRODUCTION

Antipsychotic drugs are used to treat psychosis, a severe mental illness in which people ...