May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 11
Narcotic Analgesics
LEARNING OBJECTIVES
Define analgesics and their utility
List the subtypes of opioid receptor and their functions
Describe the mode of action of narcotic analgesics
Describe the pharmacophoric requirement for a molecule to act as opioid antagonist
Describe the development of morphine and their derivatives
Illustrate the structure-activity relationship of various narcotic analgesics
Define narcotic antagonists and their utility
11.1 INTRODUCTION
Analgesics are agents that relieve pain by acting centrally to elevate pain threshold without disturbing consciousness or altering other sensory modalities. Pain is a very important protective phenomenon that accompanies many pathological conditions. However, in fulfilling ...
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