Chapter 11

Narcotic Analgesics

  • Define analgesics and their utility

  • List the subtypes of opioid receptor and their functions

  • Describe the mode of action of narcotic analgesics

  • Describe the pharmacophoric requirement for a molecule to act as opioid antagonist

  • Describe the development of morphine and their derivatives

  • Illustrate the structure-activity relationship of various narcotic analgesics

  • Define narcotic antagonists and their utility


Analgesics are agents that relieve pain by acting centrally to elevate pain threshold without disturbing consciousness or altering other sensory modalities. Pain is a very important protective phenomenon that accompanies many pathological conditions. However, in fulfilling ...

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