Medicinal Chemistry, 2nd Edition

Chapter 14

Antihistamines and Anti-Ulcer Agents

LEARNING OBJECTIVES

• Define histamines and their receptor functionality

• Define H₁ receptor antagonists and their utility

• Categorize antihistamines on the basis of the chemical nucleus

• Describe the basic structural requirement for antihistamines

• Define non-sedative antihistamines and their utility

• Define H₂ receptor antagonists and their utility

• Describe the structural requirements of a H₂ receptor antagonists

• Define H₃ and H₄ receptors and their functional utility

• Define proton pump inhibitors

• List some new drugs against histamine receptors

14.1 INTRODUCTION

Histamine [2-(imidazol-4-yl)ethylamine], which is biosynthesised by decarboxylation of the basic amino acid histidine, is found in all ...