May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 16
Antihypertensive Agents
LEARNING OBJECTIVES
Define antihypertensive agents and their utility in various conditions
Describe the mechanism of maintenance of blood pressure and their disorder
Categorize antihypertensive drugs based on the target on which they act
Describe the modes of action and their importance over other classes of antihypertensive agents
Compare α and β-adrenergic blockers
Describe the importance of angiotensin system in the treatment of hypertension
List some newer drugs for the treatment of hypertension
16.1 INTRODUCTION
The body controls blood pressure by a complex feedback mechanism between baroreceptors and effector nerves, primarily adrenergic in nature. This system is modulated by peptide systems (angiotensin/renin). ...
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