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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 16

Antihypertensive Agents

LEARNING OBJECTIVES
  • Define antihypertensive agents and their utility in various conditions

  • Describe the mechanism of maintenance of blood pressure and their disorder

  • Categorize antihypertensive drugs based on the target on which they act

  • Describe the modes of action and their importance over other classes of antihypertensive agents

  • Compare α and β-adrenergic blockers

  • Describe the importance of angiotensin system in the treatment of hypertension

  • List some newer drugs for the treatment of hypertension

16.1 INTRODUCTION

The body controls blood pressure by a complex feedback mechanism between baroreceptors and effector nerves, primarily adrenergic in nature. This system is modulated by peptide systems (angiotensin/renin). ...

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