Chapter 18

Antihyperlipidemic Agents

LEARNING OBJECTIVES

  • Define hyperlipidemia and atherosclerosis, and their causes

  • Classify antihyperlipidemics based on the structure and mode of action

  • Define HMG-CoA and its role in hyperlipidemia

  • Define the pharmacophoric requirements of the statin class of antihyperlipidemics

  • Describe some antihyperlipidemics obtained from fermentation process

  • Describe the cholesterol biosynthetic pathway and its significance

  • Define PPAR?-inhibitors and their utility

  • Describe some new drug classes useful in the treatment of hyperlipidemia and atherosclerosis

18.1 INTRODUCTION

As a regulator of homeostasis, a precursor to the corticosteroids and sex hormones, and a critical factor in the maintenance of cell-wall integrity, ...

Get Medicinal Chemistry, 2nd Edition now with the O’Reilly learning platform.

O’Reilly members experience books, live events, courses curated by job role, and more from O’Reilly and nearly 200 top publishers.

Start your free trial