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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 18

Antihyperlipidemic Agents

LEARNING OBJECTIVES
  • Define hyperlipidemia and atherosclerosis, and their causes

  • Classify antihyperlipidemics based on the structure and mode of action

  • Define HMG-CoA and its role in hyperlipidemia

  • Define the pharmacophoric requirements of the statin class of antihyperlipidemics

  • Describe some antihyperlipidemics obtained from fermentation process

  • Describe the cholesterol biosynthetic pathway and its significance

  • Define PPAR?-inhibitors and their utility

  • Describe some new drug classes useful in the treatment of hyperlipidemia and atherosclerosis

18.1 INTRODUCTION

As a regulator of homeostasis, a precursor to the corticosteroids and sex hormones, and a critical factor in the maintenance of cell-wall integrity, ...

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