May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 20
Insulin and Oral Hypoglycaemic Agents
LEARNING OBJECTIVES
Define diabetes and its types and causes
Describe the role of insulin in the body and the disease condition associated with it
Define antidiabetics and categorize based on the chemical class
Explain various strategies useful in the treatment of hyperglycaemia
Describe the mechanism of action of various classes of oral hypoglycaemic agents
Discuss the structure-activity relationship of sulphonyl ureas
List the latest drugs in the class of antidiabetics
20.1 INTRODUCTION
The pancreas contains at least four different types of endocrine cells, including A (alpha, glucagon-producing), B (beta, insulin-producing), D (delta, somatostatin-producing), and F (PP, pancreatic polypeptide-producing). ...
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