Chapter 28
Antifungal Agents
LEARNING OBJECTIVES
Define fungal infections and the treatment options
Categorize antifungals
Describe the chemistry and utility of antifungal antibiotics
Describe the mode of action and structure of azole antifungals
Discuss the utility of pyrimidine antifungals
Discuss the other structural classes of antifungals
List some new drugs in the antifungal category
28.1 INTRODUCTION
Most fungal infections (mycoses) involve superficial invasion of the skin or mucous membrane of body orifices. These diseases, which can usually be controlled by local application of antifungal agents, are divided into two etiologic groups:
- The dermatophytes, which are contagious superficial epidermal infections caused by various
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