Book description
This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.
Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.
Table of contents
- Title Page
- Copyright Page
- Contents
- Acknowledgments
- About the Author
- Preface: Thoughts on doing science
- 1. Introduction to Mobile DNA
- 2. Varieties of mobile DNA
- 3. DNA transposons
- 4. Mobile DNA of model organisms
- 5. Exceptional scientists working on mobile DNA in lower organisms
- 6. Role of bioinformatics in genome analysis
- 7. The prologue
- 8. “Welcome to the wonderful world of LINEs”
- 9. An experimental breakthrough
- 10. Reverse transcriptase to the rescue
- 11. A quirk of L1 elements—a lousy 3' end is important for genome evolution
- 12. A tour de force from Tom Eickbush
- 13. “I don’t believe all those colonies represent retrotransposition events.”
- 14. L1 encodes an endonuclease
- 15. The jocks
- 16. The mayor and the Frenchman
- 17. Ostertag’s coups
- 18. The independent Canadian
- 19. The musician scientist
- 20. Young ladies in the back bay
- 21. The brilliant young lady from China
- 22. Hiroki’s big surprises
- 23. A young man with a purpose
- 24. Other mobile DNA in mammalian genomes
- 25. Effects of retrotransposons on mammalian genomes
- 26. Host factors involved in L1 retrotransposition
- 27. Why mobile DNA?
- 28. The future of mobile DNA research
- 29. Predictions for mobile DNA
- References
- Glossary
- Index
- FT Press
Product information
- Title: Mobile DNA: Finding Treasure in Junk
- Author(s):
- Release date: March 2011
- Publisher(s): Pearson
- ISBN: 9780132575201
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