Modeling and Control for Micro/Nano Devices and Systems

5 Developing a Dynamics Model for Epidermal Growth Factor (EGF)-Induced Cellular Signaling Events

Ning Xi, Ruiguo Yang, Bo Song, King Wai Chiu Lai, Hongzhi Chen, Jennifer Y. Chen, Lynn S. Penn and Jun Xi

CONTENTS

5.1 Introduction

5.1.1 AFM Energy Dissipation and Hysteresivity Measurements

5.1.2 QCM-D Energy Dissipation Measurement

5.2 Model Development

5.2.1 AFM Viscoelastic Characterization

5.2.2 QCM-D-Based Cell Membrane Peeling Model

5.3 Results and Discussion

5.4 Conclusion

Acknowledgments

References

5.1 Introduction

Epidermal growth factor (EGF) is a growth factor that binds a cell surface receptor [1] to an epidermal growth factor receptor (EGFR), to promote cell growth and proliferation. The ligand binding can trigger a series of downstream ...