This chapter takes the principles and concepts of system of systems (SoSs) and applies them to microgrids. This chapter will define a microgrid as it pertains to the five principles of SoSs, use an SoS architecture to develop a novel way to model such a distributed electricity system, and provide a case study in the modeling and simulation of a microgrid. The first section defines a microgrid focusing on the characteristics that make it an SoS as well as how it relates to the levels of control concept. Section 13.2 introduces the dynamic data-driven application system (DDDAS) framework of a particular microgrid design. Section 13.3 provides detailed experiments and results of the DDDAS framework as it applies to microgrids. Section 13.4 forms conclusions about simulation techniques for SoSs such as microgrids and gives a foundation for further research in the areas of DDDAS and its relationship to agent-based simulation.