Modeling of Microscale Transport in Biological Processes

Chapter 13

How Dense Core Vesicles Are Delivered to Axon Terminals – A Review of Modeling Approaches

I.A. Kuznetsov^⁎,†; A.V. Kuznetsov^{‡,1    ⁎}Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States^†Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States^‡Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, United States¹Chapter coordinator.

Abstract

Dense core vesicles (DCVs) are neuronal organelles that transport diverse cargos important for neuron growth and function, such as neuropeptides, monoamines, and neurotrophic factors. Dysregulation of DCV transport is linked to numerous disorders. Neuropeptides, one of the key components ...