7. Conjunctive Long-Term Depression (LTD)

7-1. Introduction

Among electrical and chemical signaling capabilities of neurons, synaptic plasticity is a unique process that induces persistent changes in synaptic transmission efficacy in an activity-dependent manner. The best-known examples are long-term potentiation (LTP) and depression (LTD). A cascade of cellular/molecular events, which are initiated by an experience, generates these changes. They are considered to culminate in a durable form of altered synaptic transmission efficacy. “Conjunctive LTD,” which is induced postsynaptically by the combined activation of parallel fibers and a climbing fiber converging onto a Purkinje cell, is a unique type of synaptic plasticity in the cerebellum because ...

Get Modern Discoveries in Neuroscience... And What They Reveal About You (Collection) now with O’Reilly online learning.

O’Reilly members experience live online training, plus books, videos, and digital content from 200+ publishers.