siRNA-based nucleoceuticals for tissue regeneration
Abstract
The field of tissue engineering and regenerative medicine has exploded the use of small interfering RNA (siRNA) to turn off proteins that prevent the application of regenerative therapies. siRNA is a potent biomolecule for regulating the cellular behavior in tissue engineering applications, and spatially patterning its presentation to cells may ultimately facilitate the engineering of complex tissues. siRNA has a wide therapeutic application for treating diseases or augmenting tissue formation. The use of siRNA to reduce the expression of a target gene can induce the expression ...
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