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Nanostructures for Novel Therapy by Alexandru Mihai Grumezescu, Denisa Ficai

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Chapter 27

siRNA-based nucleoceuticals for tissue regeneration

Fatemeh Atyabi
Fatemeh Mottaghitalab
Ali Rastegari    Tehran University of Medical Sciences, Tehran, Iran

Abstract

The field of tissue engineering and regenerative medicine has exploded the use of small interfering RNA (siRNA) to turn off proteins that prevent the application of regenerative therapies. siRNA is a potent biomolecule for regulating the cellular behavior in tissue engineering applications, and spatially patterning its presentation to cells may ultimately facilitate the engineering of complex tissues. siRNA has a wide therapeutic application for treating diseases or augmenting tissue formation. The use of siRNA to reduce the expression of a target gene can induce the expression ...

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