Chapter 30

Role of Excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs)

Slavomira Doktorovova*
Ranjita Shegokar**
Eliana B. Souto**    University of Coimbra, Coimbra, Portugal**    Freie Universität Berlin, Berlin, Germany

Abstract

Lipid nanoparticles are widely explored in many therapeutic, targeting, and imaging areas. Among the various nanoplatforms, lipid-based nanostructures offer better attributes to drug delivery, such as high loading capacity, biocompatibility, improved physicochemical and long-term stability, ease of surface modification, adjustable drug release, and enhanced bioavailability. Despite the extensive number of publications focusing on the development of lipid nanoparticles, very limited ...

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