Chapter 2

Silk fibroin nanoparticles and cancer therapy

D. Mishra, T.S. Iyyanki, J.R. Hubenak, Q. Zhang and A.B. Mathur,    The University of Texas MD Anderson Cancer Center, Houston, TX, United States


Curcumin is a potent anticancer molecule naturally derived from the spice turmeric and was combined with silk fibroin (SF) to improve its intracellular bioavailability. This study focused on the fabrication and characterization of SF nanoparticles loaded with curcumin (SF-curcumin) and evaluated their efficacy in vitro using a metastatic breast cancer cell line (GILM2). SF-curcumin nanoparticles were characterized for particle size, morphology, curcumin loading efficiency and release kinetics, efficacy against GILM2 cells, and protein expression ...

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