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Nanotechnology in Cancer
book

Nanotechnology in Cancer

by Anshu Mathur
October 2016
Intermediate to advanced content levelIntermediate to advanced
218 pages
7h 18m
English
Elsevier
Content preview from Nanotechnology in Cancer
Chapter 2

Silk fibroin nanoparticles and cancer therapy

D. Mishra, T.S. Iyyanki, J.R. Hubenak, Q. Zhang and A.B. Mathur,    The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Abstract

Curcumin is a potent anticancer molecule naturally derived from the spice turmeric and was combined with silk fibroin (SF) to improve its intracellular bioavailability. This study focused on the fabrication and characterization of SF nanoparticles loaded with curcumin (SF-curcumin) and evaluated their efficacy in vitro using a metastatic breast cancer cell line (GILM2). SF-curcumin nanoparticles were characterized for particle size, morphology, curcumin loading efficiency and release kinetics, efficacy against GILM2 cells, and protein expression ...

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Publisher Resources

ISBN: 9780323390811