Open-Space Microfluidics

Chapter 11Microfluidic Probes for Single-Cell Proteomic Analysis

Aniruddh Sarkar^1,3, Lidan Wu^1,4 and Jongyoon Han^1,2

¹Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, MA, 02139, USA

²Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA, 02139, USA

³Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA

⁴Broad Institute of MIT and Harvard, Cambridge, MA, 02139, USA

11.1 Introduction

Molecular biology has been the main language for studying and understanding biological systems for many decades. The vast majority of analytical techniques in molecular biology require pooling molecules from a large number of cells. Hence, current understanding ...