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Pharmaceutical Analysis by P. D. Chaithanya Sudha

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Chapter 5

Particle Size Analysis

INTRODUCTION

Particle size is the physical property of the compound which influences the stability, solubility and processability. The unit for the particle size is micrometer (μm). There are different methods for the determination of the particle size, as follows:

  • Microscopy
  • Sieving method
  • Sedimentation method
  • Sensing zone method
  • Light scattering method
  • Surface area measurement method

The selection of the method is mainly based upon the following:

  • Nature of the compound
  • Solubility
  • Toxicity
  • Flowability
  • Cost
  • Specifcation requirements, etc.

Types of Diameters

  • Martin's diameter: This is the length of the line which bisects the particle.
  • Feret's diameter: this is the distance between the two tangents of the particle. ...

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